1. Genomics, Proteomics and Structural Bioinformatics of selected regulatory systems
Two component regulatory systems in streptomyces related to chitinase production and antibiotic regulation
Porin regulation in salmonella Ty21a
2.Construction of databases and development of software.
Development of an integrated membrane protein database.
Construction of proteome databases of industrial microbe streptomyces and mycobacteria
Software for whole genome and proteome comparative analysis.
RNOMICS - Development of computational tools
3.Validation and annotation of databases of selected organisms.
Annotation and functional assignment of genes for selected organisms using RNAs.
Value added annotation of disease related genes
Annotated gene expression database creation for selected organisms
4.Computational and experimental analysis of selected systems
Design of structure based inhibitors using molecular modelling
Virtual Genome simulation
Molecular modelling, dynamics and activity simulation of
Proteome analysis of streptomyces and other selected microbes